N-Methylation of Amines with Methanol in Aqueous Solution Catalyzed by a Water-Soluble Metal–Ligand Bifunctional Dinuclear Iridium Catalyst
Chong Meng, Peng Liu, Nguyễn Thanh Tùng, Xingyou Han, Feng Li
Abstract
The N-methylation of amines with methanol in aqueous solution was proposed and accomplished by using a water-soluble metal–ligand bifunctional dinuclear iridium catalyst. In the presence of [(Cp*IrCl)2(thbpym)][Cl]2 (1 mol %), a range of desirable products were obtained in high yields under environmentally benign conditions. Notably, this research exhibited the potential of transition metal-catalyzed activation of methanol as a C1 source for the construction of the C–N bond in aqueous solution.
Topics & Concepts
BifunctionalIridiumCatalysisMethanolLigand (biochemistry)ChemistryAqueous solutionMetalMethylationInorganic chemistryPolymer chemistryOrganic chemistryBiochemistryReceptorGeneAsymmetric Hydrogenation and CatalysisCarbon dioxide utilization in catalysisNanomaterials for catalytic reactions