Maternal high-fat diet increases airway sensory innervation and reflex bronchoconstriction in adult offspring
Gina N. Calco, Yem J. Alharithi, Kayla R. Williams, David B. Jacoby, A.D. Fryer, Alina Maloyan, Zhenying Nie
2023American Journal of Physiology-Lung Cellular and Molecular Physiology13 citationsDOIOpen Access PDF
Abstract
Our study reveals a novel potential mechanism, by which maternal high-fat diet increases the risk and severity of asthma in offspring. We found that exposure to maternal high-fat diet in mice leads to hyperinnervation of airway sensory nerves and increased reflex bronchoconstriction in offspring fed a regular diet only. These findings have important clinical implications and provide new insights into the pathophysiology of asthma, highlighting the need for preventive strategies in this patient population.
Topics & Concepts
BronchoconstrictionOffspringReflexMedicineSensory systemAirway hyperresponsivenessAirwayAsthmaPopulationPathophysiologyInternal medicineEndocrinologyAnesthesiaBiologyNeurosciencePregnancyEnvironmental healthGeneticsAsthma and respiratory diseasesNeuroscience of respiration and sleepNeuroendocrine regulation and behavior