Restoring Herpesvirus Entry Mediator (HVEM) Immune Function in HVEM <sup>−/−</sup> Mice Rescues Herpes Simplex Virus 1 Latency and Reactivation Independently of Binding to Glycoprotein D
Kati Tormanen, Shaohui Wang, Ujjaldeep Jaggi, Homayon Ghiasi
Abstract
HSV-1 is a common cause of ocular infections worldwide and a significant cause of preventable blindness. Corneal scarring and blindness are consequences of the immune response induced by repeated reactivation events. Therefore, HSV-1 therapeutic approaches should focus on preventing latency and reactivation. Our data suggest that the immune function of HVEM plays an important role in the HSV-1 latency and reactivation cycle that is independent of HVEM binding to gD.
Topics & Concepts
Herpes simplex virusBTLAMediatorBiologyCell biologyImmune systemDownregulation and upregulationVirologyViral replicationVirusImmunologyT cellGeneticsGeneHerpesvirus Infections and TreatmentsCytomegalovirus and herpesvirus researchinterferon and immune responses