Mechanically active small intestinal submucosa hydrogel for accelerating chronic wound healing
Xiaoya Chen, Yi Wang, Shiqing Ma, Yiqian Huang, Jing Wei, Pengfei Wei, Xueqiao Yu, Bo Zhao
Abstract
The treatment of chronic wounds is still a challenge worldwide. Here, inspired by mechanically induced embryonic wound healing, we design a mechanically active small intestinal submucosa based hydrogel (SIS-PNIPAm). The mechanical activity, biocompatibility, and bioactivity (angiogenesis and immunoregulation) of the SIS-PNIPAm hydrogel enable the fast healing of diabetic rat full-thickness wounds.
Topics & Concepts
SubmucosaWound healingMaterials scienceChronic woundSelf-healing hydrogelsMedicineBiomedical engineeringSurgeryPolymer chemistryWound Healing and TreatmentsTissue Engineering and Regenerative MedicineElectrospun Nanofibers in Biomedical Applications