Temporal profiling of therapy resistance in human medulloblastoma identifies novel targetable drivers of recurrence
David Bakhshinyan, Ashley Adile, Jeff Liu, William D. Gwynne, Yujin Suk, Stefan Custers, Ian Burns, Mohini Singh, Nicole McFarlane, Minomi Subapanditha, Maleeha Qazi, Parvez Vora, Michelle Kameda-Smith, Neil Savage, Kim L. Desmond, Nazanin Tatari, Damian Tran, Mathieu Seyfrid, Kristin J. Hope, Nicholas A. Bock, Chitra Venugopal, Gary D. Bader, Sheila K. Singh
Abstract
). Subsequent functional validation resulted in a markedly diminished in vitro proliferation, self-renewal, and longevity of MB cells, translating into extended survival and reduced tumor burden in vivo. Targeting endothelial nitric oxide synthase, a downstream substrate of BPIFB4, impeded growth of several patient-derived MB lines at low nanomolar concentrations.
Topics & Concepts
MedulloblastomaProfiling (computer programming)Gene expression profilingMedicineOncologyBioinformaticsComputational biologyCancer researchGeneBiologyGene expressionComputer scienceGeneticsOperating systemGlioma Diagnosis and TreatmentProtein Degradation and InhibitorsCaveolin-1 and cellular processes