Cefepime Precision Dosing Tool: from Standard to Precise Dose Using Nonparametric Population Pharmacokinetics
Mohammad H. Alshaer, Sylvain Goutelle, Barbara A. Santevecchi, Bethany R. Shoulders, Veena Venugopalan, Kartikeya Cherabuddi, Jiajun Liu, Patrick J. Kiel, Jason A. Roberts, Fekade Bruck Sime, Marc H. Scheetz, Michael N. Neely, Charles A. Peloquin
Abstract
> 0.98), and the median difference between what was observed and what BestDose predicted on a second occasion was 4%. For the OID, cefepime at a 0.5- to 1-g 4-h infusion every 8 to 24 h (q8 to 24 h) with a CrCl of <70 mL/min was needed to achieve a target range of free trough:MIC 1 to 4 at a MIC of 8 mg/L, while continuous infusion was needed for higher CrCl and weight values. In conclusion, we developed and validated a cefepime model for clinical application. The model was integrated in a precision dosing tool for implementation, and the median concentration prediction bias was 4%. The OID algorithm was provided.