Analysis of the correlation between immune cell characteristics and insomnia: a Mendelian randomization study
Yupeng Han, Zhiwei Song, Wangyu Li, Ke Peng, Xiaodan Wu
Abstract
This study investigated the association between 731 immune cell characteristics and insomnia using Mendelian randomization, revealing that 14 immune cell characteristics across four groups of immune traits (MFI, RC, AC, and MP) have a significant and causal association with insomnia risk. Our results contribute to the understanding of the sleep-immune cross talk doctrine and offer a new theoretical basis for immune modulation in treating insomnia.
Topics & Concepts
CD14Immune systemMendelian randomizationImmunologyInternal medicineMedicineBiologyGeneticsGeneGenotypeGenetic variantsImmune Cell Function and InteractionSleep and related disordersPediatric health and respiratory diseases