SMAD7 expression in CAR-T cells improves persistence and safety for solid tumors
Sixin Liang, Rui Zheng, Baile Zuo, Jia Li, Yiyi Wang, Yujie Han, Hao Dong, Xiaojuan Zhao, Yiting Zhang, Pengju Wang, Ruotong Meng, Lintao Jia, Angang Yang, Bo Yan
Topics & Concepts
Chimeric antigen receptorTumor microenvironmentCancer researchCytokineTransforming growth factorT cellImmunotherapyAntigenBiologyImmunologyCell biologyImmune systemTumor cellsCAR-T cell therapy researchImmune Cell Function and InteractionT-cell and B-cell Immunology