PMMA Bone Cement: Antibiotic Elution and Mechanical Properties in the Context of Clinical Use
Sebastian Philipp von Hertzberg-Boelch, Martin Lüdemann, Maximilian Rudert, Andre F. Steinert
Abstract
This literature review discusses the use of antibiotic loaded polymethylmethacrylate bone cements in arthroplasty. The clinically relevant differences that have to be considered when antibiotic loaded bone cements (ALBC) are used either for long-term implant fixation or as spacers for the treatment of periprosthetic joint infections are outlined. In this context, in vitro findings for antibiotic elution and material properties are summarized and transferred to clinical use.
Topics & Concepts
PeriprostheticBone cementContext (archaeology)AntibioticsImplantDentistryFixation (population genetics)Materials scienceCementBiomedical engineeringArthroplastyMedicineSurgeryComposite materialMicrobiologyBiologyEnvironmental healthPaleontologyPopulationOrthopedic Infections and TreatmentsOrthopaedic implants and arthroplastyTotal Knee Arthroplasty Outcomes