A Recombinant Duck Plague Virus Containing the ICP27 Deletion Marker Provides Robust Protection in Ducks
Ying Wu, Lu Liu, Mengya Zhang, Haichuan Zhan, Chenjia Wang, Mingshu Wang, Shun Chen, Renyong Jia, Qiao Yang, Dekang Zhu, Mafeng Liu, Xinxin Zhao, Shaqiu Zhang, Juan Huang, Xumin Ou, Sai Mao, Qun Gao, Di Sun, Bin Tian, Anchun Cheng
Abstract
The development of distinguishable marker vaccines from natural infection is a key step toward eradicating duck plague. Here, we generated a recombinant DPV that carries an ICP27 deletion marker that could be easily distinguished from wild-type strain by molecular biological methods.
Topics & Concepts
VirologyBiologyVirusRecombinant DNAAttenuated vaccineVirulencePlague (disease)VaccinationWaterfowlGeneGeneticsMedicineHabitatEcologyPathologyHerpesvirus Infections and TreatmentsToxoplasma gondii Research StudiesMosquito-borne diseases and control