Probing the SAM Binding Site of SARS-CoV-2 Nsp14 In Vitro Using SAM Competitive Inhibitors Guides Developing Selective Bisubstrate Inhibitors
Kanchan Devkota, Matthieu Schapira, Sumera Perveen, Aliakbar Khalili Yazdi, Fengling Li, Irene Chau, Pegah Ghiabi, Taraneh Hajian, P. Loppnau, Albina Bolotokova, K.J.F. Satchell, Ke Wang, Deyao Li, Jing Liu, David Smil, Minkui Luo, Jian Jin, Paul V. Fish, Peter J. Brown, Masoud Vedadi
Topics & Concepts
GuanosineRNAEnzymeNon-competitive inhibitionBiologyMethyltransferaseIn vitroIC50BiochemistryMethylationChemistryDNAGeneRNA modifications and cancerRNA and protein synthesis mechanismsAdvanced biosensing and bioanalysis techniques