Decreased miR-451a in cerebrospinal fluid, a marker for both cognitive impairment and depressive symptoms in Alzheimer's disease
Feng Hu, Panpan Hu, Yan Chen, Huaiqing Sun, Jiachen Cai, Xiaoxin He, Qiuchen Cao, Mengmei Yin, Yanli Zhang, Qian Li, Junying Gao, Charles Marshall, Chengyu Sheng, Jingping Shi, Ming Xiao
Abstract
This finding highlighted miR-451a as a potential target for diagnosing and treating AD, especially for those with coexisting symptoms of depression.
Topics & Concepts
NeuroinflammationCerebrospinal fluidDepression (economics)MedicineInternal medicineMicrogliaPrefrontal cortexDiseaseEndocrinologyOncologyPsychiatryCognitionInflammationMacroeconomicsEconomicsAlzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsTryptophan and brain disorders