Blood–brain barrier dysfunction in aging is mediated by brain endothelial senescence
João P. Novo, Lucy Gee, Carolina A. Caetano, Inês Tomé, Andreia Vilaça, Thomas von Zglinicki, Irina S. Moreira, Diana Jurk, Susana Rosa, Lino Ferreira
Abstract
BBB dysfunction during aging is characterized by an increase in its permeability and phenotypic alterations of brain endothelial cells (BECs) including dysregulation of tight junction's expression. Here we have investigated the role of BEC senescence in the dysfunction of the BBB. Our results suggest that the transition from young to aged BBB is mediated, at least in part by BEC senescence.
Topics & Concepts
SenescenceBlood–brain barrierBiologyCellular senescencePhenotypeEndothelial dysfunctionCell biologyBrain agingAging brainNeuroscienceEndocrinologyGeneticsGeneCentral nervous systemCognitionBarrier Structure and Function StudiesNeurological Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms