Metabolism of human pluripotent stem cells and differentiated cells for regenerative therapy: a focus on cardiomyocytes
Sho Tanosaki, Shugo Tohyama, Yoshikazu Kishino, Jun Fujita, Keiichi Fukuda
Abstract
Pluripotent stem cells (PSCs) exhibit promising application in regenerative therapy, drug discovery, and disease modeling. While several protocols for differentiating somatic cells from PSCs exist, their use is limited by contamination of residual undifferentiated PSCs and immaturity of differentiated somatic cells.The metabolism of PSCs differs greatly from that of somatic cells, and a distinct feature is required to sustain the distinct properties of PSCs. To date, several studies have reported on the importance of metabolism in PSCs and their derivative cells. Here, we detail advancements in the field, with a focus on cardiac regenerative therapy.
Topics & Concepts
Regenerative medicineInduced pluripotent stem cellHuman Induced Pluripotent Stem CellsCell biologyStem cellCell therapyFocus (optics)Cellular differentiationBiologyNeuroscienceEmbryonic stem cellBiochemistryGenePhysicsOpticsMitochondrial Function and PathologyATP Synthase and ATPases ResearchPluripotent Stem Cells Research