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Alcohol-free hand sanitizer and other quaternary ammonium disinfectants quickly and effectively inactivate SARS-CoV-2

Benjamin Ogilvie, Antonio Solis‐Leal, Joel Lopez, Brian D. Poole, Richard A. Robison, Bradford K. Berges

2020Journal of Hospital Infection106 citationsDOIOpen Access PDF

Abstract

BACKGROUND: SARS-CoV-2 is the virus responsible for the current global pandemic, COVID-19. Because this virus is novel, little is known about its sensitivity to disinfection. METHODS: We performed suspension tests against SARS-CoV-2 using three commercially available quaternary ammonium compound (Quat) disinfectants and one laboratory-made 0.2% benzalkonium chloride solution. FINDINGS: Three of the four formulations completely inactivated the virus within 15 s of contact, even in the presence of a soil load or when diluted in hard water. CONCLUSION: Quats rapidly inactivate SARS-CoV-2, making them potentially useful for controlling SARS-CoV-2 spread in hospitals and the community.

Topics & Concepts

Benzalkonium chlorideHand sanitizerSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)VirologyAmmonium chlorideAmmoniumCoronavirus disease 2019 (COVID-19)VirusMicrobiologyChemistry2019-20 coronavirus outbreakBiologyChromatographyMedicineFood scienceOrganic chemistryDiseaseOutbreakPathologyInfectious disease (medical specialty)Antimicrobial agents and applicationsMedical Device Sterilization and DisinfectionEnvironmental Chemistry and Analysis
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