Effect of polycation nanostructures on cell membrane permeability and toxicity
Magdalena Wytrwał-Sarna, Paulina Knobloch, Sławomir Lasota, Marta Michalik, Maria Nowakowska, Mariusz Kępczyński
Abstract
Amphiphilic polycations with quaternary ammonium groups show a strong tendency to porate lipid membranes. The polycations with a high capacity to open pores in biomembranes are the most cytotoxic to cells.
Topics & Concepts
MembraneAmphiphileAmmoniumChemistryPermeability (electromagnetism)BiophysicsMembrane permeabilityToxicityChemical engineeringNanostructureMaterials scienceNanotechnologyBiochemistryOrganic chemistryCopolymerPolymerBiologyEngineeringAntimicrobial agents and applicationsMolecular Sensors and Ion DetectionLuminescence and Fluorescent Materials