An electrochemical cascade process: synthesis of 3-selenylindoles from 2-alkynylanilines with diselenides
Anil Balajirao Dapkekar, Gedu Satyanarayana
Abstract
Substituted organoselenium compounds are crucial structural motifs in pharmaceutical molecules. Herein, we report a metal, oxidant, and base-free electrochemical approach to access 3-selenylindoles through an oxidative cyclization of 2-alkynylanilines with diselenides. This environmentally friendly approach demonstrates a wide range of substrate scope under mild reaction conditions in an electrochemical undivided cell setup.
Topics & Concepts
ElectrochemistryCombinatorial chemistryEnvironmentally friendlyCascadeSubstrate (aquarium)Scope (computer science)Base (topology)MoleculeChemistryProcess (computing)NanotechnologyMaterials scienceOrganic chemistryComputer scienceMathematicsBiologyOperating systemEcologyMathematical analysisPhysical chemistryElectrodeProgramming languageGeologyChromatographyOceanographySulfur-Based Synthesis TechniquesRadical Photochemical ReactionsCatalytic C–H Functionalization Methods