Memory CD8 <sup>+</sup> T cells mediate early pathogen-specific protection via localized delivery of chemokines and IFNγ to clusters of monocytes
Marie Boutet, Zachary Benet, Erik Guillen, Caroline Koch, Saïdi M. Soudja, Fabien Delahaye, David Fooksman, Grégoire Lauvau
Abstract
Protection in vaccinated hosts occurs quickly upon pathogen-specific memory CD8 + T cell–mediated activation of myeloid cells.
Topics & Concepts
ChemokinePathogenMonocyteCell biologyCD8BiologyImmunologyChemistryInflammationImmune systemT-cell and B-cell ImmunologyImmune Cell Function and InteractionImmunotherapy and Immune Responses