c-di-AMP Is Essential for the Virulence of <i>Enterococcus faecalis</i>
Shivani Kundra, Ling Ning Lam, Jessica K. Kajfasz, Leila G. Casella, Marissa J. Andersen, Jacqueline Abranches, Ana L. Flores‐Mireles, José A. Lemos
Abstract
Second messenger nucleotides are produced by bacteria in response to environmental stimuli and play a major role in the regulation of processes associated with bacterial fitness, including but not limited to osmoregulation, envelope homeostasis, central metabolism, and biofilm formation. In this study, we uncovered the biological significance of c-di-AMP in the opportunistic pathogen Enterococcus faecalis by isolating and characterizing strains lacking genes responsible for c-di-AMP synthesis ( cdaA ) and degradation ( dhhP and gdpP ).
Topics & Concepts
Enterococcus faecalisBiologyVirulenceBiofilmMicrobiologyBacteriaPathogenMicrobial metabolismOsmoregulationEnterococcusGeneBiochemistryAntibioticsGeneticsEcologyStaphylococcus aureusSalinityAntimicrobial Resistance in StaphylococcusBacterial biofilms and quorum sensingAntimicrobial Peptides and Activities