Genetic Network Architecture and Environmental Cues Drive Spatial Organization of Phenotypic Division of Labor in Streptomyces coelicolor
Vineetha M. Zacharia, Yein Ra, Catherine Sue, Elizabeth Alcala, Jewel N. Reaso, Steven E. Ruzin, Matthew F. Traxler
Abstract
Streptomyces coelicolor is a multicellular bacterium that differentiates into specialized cell types and produces a diverse array of natural products. While much is known about the genetic networks that regulate development and antibiotic biosynthesis in S. coelicolor , what drives the spatial organization of these activities within a colony remains to be explored.
Topics & Concepts
Streptomyces coelicolorMulticellular organismStreptomycesBiologyPhenotypeSpatial organizationGenetic architectureDivision of labourComputational biologyGeneticsEvolutionary biologyBacteriaGeneEconomicsMarket economyMicrobial Natural Products and BiosynthesisSynthetic Organic Chemistry MethodsChemical Synthesis and Analysis