Plasma-derived DNA containing-extracellular vesicles induce STING-mediated proinflammatory responses in dermatomyositis
Yubin Li, Christina E. Bax, Jay Patel, Thomas Vazquez, Adarsh Ravishankar, Muhammad M. Bashir, Madison Grinnell, DeAnna Diaz, Victoria P. Werth
Abstract
Plasma-derived, DNA containing-EVs induced STING-mediated proinflammatory effects in DM. Targeting the STING pathway may be a potential therapeutic approach for DM.
Topics & Concepts
Proinflammatory cytokineStingStimulator of interferon genesSignal transductionCell biologyImmunologyInflammasomeInflammationChemistryMedicineBiologyInnate immune systemImmune systemAerospace engineeringEngineeringinterferon and immune responsesInflammasome and immune disordersCytokine Signaling Pathways and Interactions