PGC1α is required for the renoprotective effect of lncRNA Tug1 in vivo and links Tug1 with urea cycle metabolites
Li Li, Jianyin Long, Koki Mise, Daniel L. Galvan, Paul A. Overbeek, Lin Tan, Shwetha V. Kumar, Wai Kin Chan, Phillip L. Lorenzi, Benny Hung‐Junn Chang, Farhad R. Danesh
Abstract
) reverses the protective phenotype of Tug1 overexpression, suggesting that PGC1α is required for the renoprotective effect of Tug1. Using unbiased metabolomic profiling, we find that altered urea cycle metabolites and mitochondrial arginase 2 play an important role in Tug1/PGC1α-induced mitochondrial remodeling. Our work identifies a functional role of the Tug1/PGC1α axis on mitochondrial metabolic homeostasis and urea cycle metabolites in experimental models of diabetes.
Topics & Concepts
In vivoChemistryPharmacologyUreaBiologyBiochemistryBiotechnologyCancer-related molecular mechanisms researchMetabolism and Genetic DisordersEpigenetics and DNA Methylation