Widespread Dissemination of Plasmid-Mediated Tigecycline Resistance Gene <i>tet</i> (X4) in <i>Enterobacterales</i> of Porcine Origin
Qin Wang, Changwei Lei, Hansen Cheng, Xue Yang, Zheren Huang, Xuan Chen, Zijing Ju, Haoyu Zhang, Hongning Wang
Abstract
Tigecycline is considered to be the last resort of defense against diseases caused by broad-spectrum resistant Gram-negative bacteria. In this study, we systematically analyzed the prevalence and genetic environments of the resistance gene tet (X4) in a pig slaughterhouse and farms and the evolutionary relationship of 533 tet (X4)-positive Escherichia coli strains, including 509 tet (X4)-positive E. coli strains selected from the 27,802 assembled genomes of E. coli from the NCBI between 2002 and 2022.
Topics & Concepts
TigecyclineBiologyPlasmidMicrobiologyEscherichia coliRepliconPhylogenetic treeGenomeGeneInsertion sequenceWhole genome sequencingKlebsiella oxytocaBacteriaGeneticsEnterobacteriaceaeTransposable elementAntibioticsAntibiotic Resistance in BacteriaPharmaceutical and Antibiotic Environmental ImpactsBacteriophages and microbial interactions