A biocompatible pure organic porous nanocage for enhanced photodynamic therapy
Zhong‐Hong Zhu, Di Zhang, Jian Chen, Hua‐Hong Zou, Zhiqiang Ni, Y. Jeffrey Yang, Yating Hu, Ruiyuan Liu, Guangxue Feng, Ben Zhong Tang
Abstract
animal experiments further confirm the excellent antitumor activity of the Py-Cage. As compared to conventional metal coordination approaches to improve PDT efficacy of porphyrin derivatives, the pure organic porous Py-Cage demonstrates excellent biocompatibility, which is further verified in both mice and rats. This work of an organic porous nanocage shall provide a new paradigm for the design of novel, biocompatible and effective photosensitizers for PDT.
Topics & Concepts
NanocagesPhotodynamic therapyPorphyrinReactive oxygen speciesStackingSinglet oxygenBiocompatibilityPhotochemistryMaterials scienceChemistryPorosityNanotechnologyOxygenOrganic chemistryCatalysisBiochemistryNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesPorphyrin and Phthalocyanine Chemistry