Interplay between Porphyromonas gingivalis Hemophore-Like Protein HmuY and Kgp/RgpA Gingipains Plays a Superior Role in Heme Supply
Michał Śmiga, Paulina Ślęzak, Mateusz Wagner, Teresa Olczak
Abstract
Altered or disturbed mutualism between oral microbiome members results in dysbiosis with local injuries and subsequently in systemic diseases. Periodontitis belongs to a group of multifactorial infectious diseases, characterized by inflammation and destruction of tooth-supporting tissues. Porphyromonas gingivalis is considered the main etiologic agent and keystone pathogen responsible for developing advanced periodontitis.
Topics & Concepts
Porphyromonas gingivalisHemeVirulenceHemeproteinMicrobiologyProtoporphyrin IXChemistryVirulence factorBiologyGeneBiochemistryBacteriaGeneticsEnzymePhotodynamic therapyOrganic chemistryOral microbiology and periodontitis researchStreptococcal Infections and TreatmentsHeme Oxygenase-1 and Carbon Monoxide