Initial treatment with a single pill containing quadruple combination of quarter doses of blood pressure medicines versus standard dose monotherapy in patients with hypertension (QUARTET): a phase 3, randomised, double-blind, active-controlled trial
Clara K Chow, Emily Atkins, Graham S. Hillis, Mark Nelson, Christopher M. Reid, Markus P. Schlaich, Peter Hay, Kris Rogers, Laurent Billot, Michael Burke, John Chalmers, Bruce Neal, Anushka Patel, Tim Usherwood, Ruth Webster, Anthony Rodgers, Andrew Hung, Armand Edison, Angalie E Abraham, Daniel Xu, Mark T. Bloch, Gemma A. Figtree, Janis M. Nolde, Andrew Black, Shirley Jansen, Sinjini Biswas, Andrew E. Ajani, Revathy Carnagarin, D. Wynne, M. Altman, Jay Thakkar, Aravinda Thiagalingam, Harry Klimis
Topics & Concepts
MedicineTolerabilityBlood pressureIrbesartanPillClinical trialRandomized controlled trialIntention-to-treat analysisDiscontinuationIndapamideInternal medicineAmlodipineAdverse effectPhysical therapyPharmacologyBlood Pressure and Hypertension StudiesHeart rate and cardiovascular healthMedication Adherence and Compliance