Carvacrol preserves antioxidant status and attenuates kidney fibrosis <i>via</i> modulation of TGF-β1/Smad signaling and inflammation
Chetan Ram, Shobhit Gairola, Abu Mohammad Syed, Shobhit Verma, Madhav Nilakanth Mugale, Bidya Dhar Sahu
Abstract
study also confirmed that CVL inhibits the EMT process in TGF-β1 stimulated renal tubular epithelial cells (NRK 52E cells). Collectively, our findings indicate that CVL administration attenuates kidney fibrosis by targeting oxidative stress and inflammation.
Topics & Concepts
KidneyFibrosisSMADTransforming growth factorInflammationEndocrinologySuperoxide dismutaseInternal medicineMyofibroblastMedicineChemistryCancer researchOxidative stressChronic Kidney Disease and DiabetesAcute Kidney Injury ResearchDialysis and Renal Disease Management