Force-induced gene up-regulation does not follow the weak power law but depends on H3K9 demethylation
Jian Sun, Junwei Chen, Erfan Mohagheghian, Ning Wang
Abstract
near the nuclear periphery, whereas H3K9me3 hypermethylation has opposite effects. Our findings demonstrate that rapid up-regulation of endogenous mechanoresponsive genes depends on H3K9me3 demethylation.
Topics & Concepts
Transcription (linguistics)DemethylationEpigeneticsRegulation of gene expressionCell biologyBiologyPromoterTranscriptional regulationTranscription factorGene expressionDNA methylationGeneGeneticsChemistryMolecular biologyPhilosophyLinguisticsCellular Mechanics and InteractionsRNA Research and SplicingGenomics and Chromatin Dynamics