The porphyrin TMPyP4 inhibits elongation during the noncanonical translation of the FTLD/ALS-associated GGGGCC repeat in the C9orf72 gene
Kohji Mori, Shiho Gotoh, Tomoko Yamashita, Ryota Uozumi, Yuya Kawabe, Shinji Tagami, Frits Kamp, Brigitte Nuscher, Dieter Edbauer, Christian Haass, Yoshitaka Nagai, Manabu Ikeda
Abstract
repeat translation elongation.
Topics & Concepts
C9orf72Trinucleotide repeat expansionRNARibosomePolysomeTranslation (biology)Protein biosynthesisChemistryCell biologyBiologyMolecular biologyGeneMessenger RNABiochemistryAlleleAmyotrophic Lateral Sclerosis ResearchNeurogenetic and Muscular Disorders ResearchNeurological diseases and metabolism