Next-Generation Probiotics - The Future of Biotherapeutics
Md. Fakruddin, Zainab Yousuf, Zainab Yousuf, A Adak, M Khan, M Ahmed, A Chowdhury, R Malaker, M Hossain, M Fakruddin, R Noor, J Andrade, D Almeida, M Domingos, C Seabra, D Machado, A Freitas, A Gomes, A Anvar, B Nowruzi, M Bilen, J Dufour, J Lagier, F Cadoret, Z Daoud, G Dubourg, D Raoult, F Bottacini, D Van Sinderen, M Ventura, T Brodmann, A Endo, M Gueimonde, G Vinderola, W Kneifel, W De Vos, S Salminen, C Gmez-Gallego, J Breton, M Galmiche, P Dechelotte, P Bron, M Kleerebezem, R.-J Brummer, Cani, A Mercenier, T Macdonald, C Garcia-Rodenas, J Wells, V Bunesova, C Lacroix, C Schwab, M Byndloss, E Olsan, F Rivera-Chavez, C Tiffany, S Cevallos, K Lokken, Unknown author, A Baumler, P Cani, W De Vos, A Carlsson, O Yakymenko, I Olivier, F Hkansson, E Postma, Keita, J Sderholm, N Cassir, S Benamar, La Scola, B, C.-J Chang, C.-S Lin, C.-C Lu, J Martel, Y.-F Ko, D Ojcius, Unknown author, H.-C Lai, C Chang, T Lin, Y Tsai, Lai, H.-C, N Chaput, P Lepage, C Coutzac, Unknown author, F Carbonnel, D Chen, D Jin, S Huang, J Wu, M Xu, T Liu, W Dong, X Liu, S Wang
Abstract
Lactic acid bacteria, most of which are represented by the genera Lactobacilli and Bifidobacteria, have been extensively investigated for their role as probiotics and have also been used in food items due to their advantageous metabolic properties in manufacturing fermented food. To expand the spectrum of probiotics, there is currently a great deal of interest in researching different microorganisms with potential health benefits for humans. These next-generation probiotics are bacteria that mostly come from the Bacteroides, Clostridium, Faecalibacterium, and Akkermansia genera. However, studying these microbes as probiotics and using them in food production can become extremely problematic. Understanding its efficacy and safety for consumption, as well as its application in the production of new food items and industrial-scale food production, are among some of the challenges faced. The next generation of probiotics has become a major topic in scientific research as well as the food sector and poses new obstacles as it gets studied further.