<i>Sargassum fusiforme</i>polysaccharide is a potential auxiliary substance for metformin in the management of diabetes
Juan Wu, Rui‐Bo Jia, Donghui Luo, Zhao‐Rong Li, Lianzhu Lin, Qianwen Zheng, Mouming Zhao
Abstract
exhibited higher levels in the LMET-SFP group compared to the metformin group. RT-qPCR results demonstrated that the better hypoglycemic effects of LMET-SFP were mainly attributed to the down-regulation of 3-hydroxy-3-methylglutaryl-coenzyme A, cytosolic phosphoenolpyruvate carboxykinase and glucose-6-phosphatase expression, and the up-regulation of cholesterol 7α-hydroxylase expression, in contrast to metformin alone. These results suggest that SFP may be used as an auxiliary hypoglycemic substance for metformin in the future.
Topics & Concepts
MetforminPolysaccharideDiabetes mellitusChemistryBusinessPharmacologyTraditional medicineMedicineBiochemistryEndocrinologyNatural Antidiabetic Agents StudiesMicrobial Metabolites in Food BiotechnologyDiet, Metabolism, and Disease