Iron-catalyzed asymmetric Csp<sup>3</sup>–H/Csp<sup>3</sup>–H coupling: improving the chirality induction by mechanochemical liquid-assisted grinding
Ping Ying, Ying Tao, Hong Chen, Keyu Xiang, Weike Su, Haijiao Xie, Jingbo Yu
Abstract
A mechanochemical iron-catalyzed asymmetric oxidative coupling between glycines and β-ketoesters has been disclosed, utilizing t -BuOH to improve the enantioselectivity and stabilize the iminium intermediate via intensified hydrogen bond interactions.
Topics & Concepts
ChemistryGrindingCatalysisChirality (physics)Asymmetric inductionCoupling (piping)Chemical engineeringOrganic chemistryMetallurgyEnantioselective synthesisPhysicsQuantum mechanicsNambu–Jona-Lasinio modelMaterials scienceChiral symmetry breakingEngineeringQuarkAlkaloids: synthesis and pharmacologyAxial and Atropisomeric Chirality SynthesisMicrobial Natural Products and Biosynthesis