Mechanism and treatment of diarrhea associated with tyrosine kinase inhibitors
Jiangnan Liu, Shuai Yan, Juntong Du, Lizhi Teng, Ru Yang, Peng Xu, Weiyang Tao
Abstract
Tyrosine kinase inhibitors (TKIs) have become first-line drugs for cancer treatment. However, their clinical use is seriously hindered since many patients experience diarrhea after receiving TKIs. The mechanisms of TKI-associated diarrhea remain unclear. Most existing therapies are symptomatic treatments based on experience and their effects are unsatisfactory. Therefore, clarification of the mechanisms underlying diarrhea is critical to develop effective anti-diarrhea drugs. This article summarizes several potential mechanisms of TKI-associated diarrhea and reviews current treatment progress.
Topics & Concepts
Mechanism (biology)DiarrheaTyrosine kinaseMedicineTyrosine-kinase inhibitorCancer researchIntensive care medicineBioinformaticsPharmacologyInternal medicineBiologyCancerReceptorPhilosophyEpistemologyGastric Cancer Management and OutcomesColorectal Cancer Treatments and StudiesPI3K/AKT/mTOR signaling in cancer