Ferroptosis/pyroptosis dual-inductive combinational anti-cancer therapy achieved by transferrin decorated nanoMOF
Rui Xu, Jie Yang, Yun Qian, Huizi Deng, Zhihua Wang, Siyu Ma, Yawen Wei, Ning Yang, Qi Shen
Abstract
for the dual induction system to increase ROS generation through Fenton reaction. On the basis of validation of both ferroptosis and pyroptosis, the dual-inductive nanodrug demonstrated ideal anticancer effects in the xenograft mice model, which proved that the ferroptosis/pyroptosis dual-inductive nanoplatform could be an effective and promising anticancer modality.
Topics & Concepts
PyroptosisCancer therapyTransferrinCancer researchCancerDual (grammatical number)MedicineChemistryApoptosisProgrammed cell deathInternal medicineBiochemistryLiteratureArtNanoplatforms for cancer theranosticsExtracellular vesicles in diseaseFerroptosis and cancer prognosis