Design, synthesis, and <i>in vitro</i> and <i>in vivo</i> anticancer activity studies of new (<i>S</i>)-Naproxen thiosemicarbazide/1,2,4-triazole derivatives
M. İhsan Han, Cansu Ümran Tunç, Pınar Atalay, Ömer Erdoğan, Gökhan Ünal, Nuh Mehmet Bozkurt, Ömer Aydın, Özge Çevik, Ş. Güniz Küçükgüzel
Abstract
This study includes the synthesis of new Naproxen derivatives and in vitro – in vivo molecular mechanistic studies.
Topics & Concepts
ChemistryNaproxenIn vivoIn vitroTriazoleStereochemistryCombinatorial chemistryBiochemistryOrganic chemistryBiologyBiotechnologyMedicineAlternative medicinePathologyClick Chemistry and ApplicationsSynthesis and biological activitySynthesis and Catalytic Reactions