Responsive hydrogel modulator with self-regulated polyphenol release for accelerating diabetic wound healing <i>via</i> precise immunoregulation
Yunfei Tan, Лей Ма, Yixuan Wu, Zeng Yi, Xiaomin Ma, Jiaxin Liu, Ye Cao, Xudong Li
Abstract
rat wound healing model experiment results confirmed that these hydrogels promoted collagen deposition and granulation tissue regeneration, accelerating diabetic wound healing. Based on the protease-responsive degradation characteristic of the hydrogels and high protease activity in the diabetic wound microenvironment, hydrogels with exquisite polyphenol release controllability are promising candidates as dressings for diabetic wound management.
Topics & Concepts
Wound healingSelf-healing hydrogelsSelf-healingPolyphenolOxidative stressMacrophage polarizationControlled releaseMaterials scienceOxidative damageBiomedical engineeringChemistryNanotechnologyMedicineMacrophageSurgeryBiochemistryPolymer chemistryPathologyIn vitroAntioxidantAlternative medicineWound Healing and TreatmentsDiabetic Foot Ulcer Assessment and ManagementHydrogels: synthesis, properties, applications