Repurposing Fenamic Acid Drugs To Combat Multidrug-Resistant Neisseria gonorrhoeae
Young Jin Seong, Marwa Alhashimi, Abdelrahman S. Mayhoub, Haroon Mohammad, Mohamed N. Seleem
Abstract
The rise of extensively drug-resistant and multidrug-resistant strains of Neisseria gonorrhoeae has occurred in parallel with the increasing demand for new drugs. However, the current methods of drug discovery are burdened with rigorous assessments and require more time than can be spared until gonococcal infections become difficult to control. To address this urgency, we utilized a drug-repurposing strategy and identified three clinically approved anthranilic acid drugs (tolfenamic acid, flufenamic acid, and meclofenamic acid) with potent antigonococcal activity, inhibiting 50% of the strains (MIC 50 ) from 4 to 16 μg/ml.
Topics & Concepts
Neisseria gonorrhoeaeDrug repositioningPharmacologyDrugMultiple drug resistanceFlufenamic acidMedicineRepurposingAntibioticsMicrobiologyBiologyEcologyReproductive tract infections researchBacterial Infections and VaccinesAmoebic Infections and Treatments