Fast Heck–Cassar–Sonogashira (HCS) Reactions in Green Solvents
Lucia Ferrazzano, Giulia Martelli, Tommaso Fantoni, A. Daka, Dario Corbisiero, Angelo Viola, Antônio Ricci, Walter Cabri, Alessandra Tolomelli
Abstract
-Hydroxyethylpyrrolidone (HEP) gave the best results. Moreover, the methodology was successfully applied to the synthesis of an intermediate of the anticancer drug Erlotinib, demonstrating the versatility of the new green protocol.
Topics & Concepts
Sonogashira couplingChemistryCombinatorial chemistryHeck reactionOrganic chemistryPalladiumCatalysisCatalytic Cross-Coupling ReactionsChemical Synthesis and ReactionsChemical Synthesis and Analysis