Rearranged <scp>Dichapetalin‐Type</scp> Triterpenoids with Cytotoxic Activity from <i>Dichapetalum gelonioides</i>
Xinhua Gao, Xi‐Yuan Wang, Jun‐Su Zhou, Yan Zhang, Hong‐Chun Liu, Bin Zhou, Jian‐Min Yue
Abstract
Comprehensive Summary Dichagelinoids A—C (1—3), three unusual dichapetalin‐type triterpenoids, together with two biogenetically related derivatives dichagelinoids D and E (4 and 5) were isolated and characterized by solid data from Dichapetalum gelonioides . Compounds 1—3 possess a common rearranged C ring and different C6—C2 modified motifs at the A rings. Biological evaluation revealed that compounds 1—3 showed distinct cytotoxic activity against the tested human cancer cell lines.
Topics & Concepts
ChemistryCytotoxic T cellTriterpenoidStereochemistryCancer cell linesTerpeneCytotoxicityCancer cellCancerBiochemistryIn vitroInternal medicineMedicinePhytochemical compounds biological activitiesNatural product bioactivities and synthesisSesquiterpenes and Asteraceae Studies