Palladium mono-<i>N</i>-protected amino acid complexes: experimental validation of the ligand cooperation model in C–H activation
Sara Fernández-Moyano, Vanesa Salamanca, Ana C. Albéniz
Abstract
Me coupling products. This process takes place only for the ligands with an acyl protecting group, showing the cooperating role of this group in a complex with a chelating MPAA, therefore experimentally validating this working model. The carboxylate group is inefficient in this C-H activation.
Topics & Concepts
PalladiumLigand (biochemistry)ChemistryChelationCarboxylateTolueneStereochemistryMedicinal chemistryCatalysisReceptorOrganic chemistryBiochemistryCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsAsymmetric Hydrogenation and Catalysis