Sustained postsynaptic kainate receptor activation downregulates AMPA receptor surface expression and induces hippocampal LTD
Jithin D. Nair, Ellen Braksator, Busra P. Yucel, Alexandra Fletcher-Jones, Richard Seager, Jack R. Mellor, Zafar I. Bashir, Kevin A. Wilkinson, Jeremy M. Henley
Abstract
, demonstrate that KARs can bidirectionally regulate synaptic AMPARs and synaptic plasticity via different signaling pathways.
Topics & Concepts
AMPA receptorKainate receptorLong-term depressionPostsynaptic potentialIonotropic effectExcitatory postsynaptic potentialChemistrySynaptic plasticityNMDA receptorGlutamate receptorHippocampal formationNeuroscienceSilent synapseKainic acidCell biologyReceptorBiologyBiochemistryNeuroscience and Neuropharmacology ResearchIon channel regulation and functionReceptor Mechanisms and Signaling