Dipleosporalones A and B, Dimeric Azaphilones from a Marine-Derived <i>Pleosporales</i> sp. Fungus
Fei Cao, Zhi-Hui Meng, Pu Wang, Du‐Qiang Luo, Hua‐Jie Zhu
Abstract
Dipleosporalones A and B (1 and 2), two new [2 + 2] azaphilone dimers, were obtained from a marine-derived Pleosporales sp. fungus. The absolute configurations of 1 and 2 were elucidated by calculations of their ECD spectra. Dipleosporalone A (1) possessed an unprecedented skeleton with an uncommon 6/4/6 ring system. Compounds 1 and 2 showed cytotoxicity about 30–90-fold more potent than that of their monomer pinophilin B.
Topics & Concepts
StereochemistryFungusCytotoxicityMonomerChemistryAbsolute configurationBiologyBotanyBiochemistryOrganic chemistryIn vitroPolymerMarine Sponges and Natural ProductsMicrobial Natural Products and BiosynthesisFungal Biology and Applications