Vesicular Glutamate Transporters (SLCA17 A6, 7, 8) Control Synaptic Phosphate Levels
Cyril Chéret, Marcelo Ganzella, Julia Preobraschenski, Reinhard Jahn, Gudrun Ahnert‐Hilger
Abstract
)/Pi (NaPi)-uptake mediated by VGLUTs but does not appear to be transported. A nanobody that blocks glutamate transport by binding to the cytoplasmic domain of VGLUT1 abolishes Pi transport when co-expressed with VGLUT1. We conclude that VGLUTs have a dual function that is essential for both vesicular glutamate loading and Pi restoration in neurons.
Topics & Concepts
Glutamate receptorExcitatory amino-acid transporterTransporterPhosphateChemistryNeuroscienceNeurotransmitterBiologyCell biologyBiochemistryCentral nervous systemGeneReceptorNeuroscience and Neuropharmacology ResearchPhotoreceptor and optogenetics researchMitochondrial Function and Pathology