Glycomic Analysis Reveals a Conserved Response to Bacterial Sepsis Induced by Different Bacterial Pathogens
Daniel W. Heindel, Shuhui Chen, Peter V. Aziz, JH Chung, Jamey D. Marth, Lara K. Mahal
Abstract
-glycan shift. Analysis of this band by mass spectrometry identified interalpha-trypsin inhibitor heavy chains (ITIHs) and fibronectin, both of which are associated with human sepsis. Shifts in the glycosylation of these proteins were observed. Overall, our work points toward a common mechanism for bacterially induced sepsis, marked by conserved changes in the glycome.
Topics & Concepts
BiologySepsisMicrobiologyComputational biologyImmunologyProbiotics and Fermented FoodsAntimicrobial Resistance in StaphylococcusPneumonia and Respiratory Infections