Chiral phosphoric acids: a chiral lobby for enantioselective C–H activation
Sumit, Devesh Chandra, Upendra Sharma
Abstract
Enantioselective C-H activation is one of the promising methods to obtain enantiopure molecules in high enantiomeric excess with excellent control of regio and chemo-selectivity. The chiral phosphoric acids have evolved as the leading ligands in the enantioselective C-H activation. Chiral phosphoric acids can interact in different ways with the substrate to induce chirality into the system. This review summarizes the use of chiral phosphoric acids in the exciting field of enantioselective C-H activation.
Topics & Concepts
Enantioselective synthesisEnantiopure drugPhosphoric acidEnantiomerChirality (physics)ChemistrySubstrate (aquarium)SelectivityStereochemistryCombinatorial chemistryOrganic chemistryCatalysisChiral anomalyBiologyPhysicsNambu–Jona-Lasinio modelQuantum mechanicsEcologyFermionCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsAsymmetric Hydrogenation and Catalysis