Dissecting the biology of mTORC1 beyond rapamycin
Guang Yang, Deanne Francis, James R. Krycer, Mark Larance, Ziyang Zhang, Chris J. Novotny, Alexis Díaz‐Vegas, Kevan M. Shokat, David E. James
Abstract
. Consistent with the effects of RapaLink1, genetic blockade of mTORC1 activity made flies more sensitive to starvation, reflecting the complexity of the mTORC1 network that extends beyond effects that can be inhibited by rapamycin. These findings extend our understanding of mTOR biology and provide insights into some of the beneficial effects of rapamycin.
Topics & Concepts
mTORC1mTORC2PI3K/AKT/mTOR pathwayMechanistic target of rapamycinBiologyCell biologyAutophagyKinasePhosphorylationRPTORSignal transductionBiochemistryApoptosisAutophagy in Disease and TherapyPI3K/AKT/mTOR signaling in cancerGenetics, Aging, and Longevity in Model Organisms