Characterization, mechanisms, structure–activity relationships, and antihypertensive effects of ACE inhibitory peptides: rapid screening from sufu hydrolysate
Jianfei Li, Haohan Hu, Feng Chen, Chenying Yang, Wanzhou Yang, Yuexin Pan, Xiaodong Yu, Qiyi He
Abstract
studies using spontaneously hypertensive rats demonstrated significant reductions in both systolic and diastolic blood pressure, indicating that AWR and LLR have strong antihypertensive potential. This study illustrates that ultrafiltration, combined with LC-MS/MS and bioinformatics analysis, is an effective approach for the rapid screening of ACE inhibitory peptides. These results not only enhance our understanding of sufu-derived peptides but also offer promising implications for hypertension management.
Topics & Concepts
HydrolysateChemistryInhibitory postsynaptic potentialPharmacologyVirtual screeningBiochemistryBiologyEndocrinologyDrug discoveryHydrolysisProtein Hydrolysis and Bioactive PeptidesBiochemical effects in animalsNeuropeptides and Animal Physiology