Radiation-Induced Fibrosis in Patients with Head and Neck Cancer: A Review of Pathogenesis and Clinical Outcomes
Paul Ramia, Larry Bodgi, Dima Mahmoud, Mohammad A. Mohammad, Bassem Youssef, Neil Kopek, Humaid O. Al‐Shamsi, Mona Dagher, Ibrahim Abu‐Gheida
Abstract
Radiotherapy-related fibrosis remains one of the most challenging treatment related side effects encountered by patients with head and neck cancer. Several established and ongoing novel therapies have been studied with paucity of data in how to best treat these patients. This review aims to provide researchers and health care providers with a comprehensive review on the presentation, etiology, and therapeutic options for this serious condition.
Topics & Concepts
MedicineHead and neck cancerEtiologyRadiation therapyPresentation (obstetrics)Head and neckIntensive care medicineCancerPathogenesisBioinformaticsOncologyInternal medicineSurgeryBiologyHead and Neck Cancer StudiesOral health in cancer treatmentEffects of Radiation Exposure