Novel pyrrolo[2,1-c][1,4]benzodiazepine-3,11-dione (PBD) derivatives as selective HDAC6 inhibitors to suppress tumor metastasis and invasion in vitro and in vivo
Yanchun Li, Jishun Quan, Haoxuan Song, Dongzhu Li, Enlong Ma, Yanjuan Wang, Chao Ma
Topics & Concepts
HDAC6ChemistryIn vivoIn vitroAcetylationHydroxamic acidVorinostatPharmacologyHistone deacetylaseBiochemistryCancer researchHistoneStereochemistryBiologyBiotechnologyGeneHistone Deacetylase Inhibitors ResearchPeptidase Inhibition and AnalysisProtein Degradation and Inhibitors