Oxidation of peroxiredoxin-4 induces oligomerization and promotes interaction with proteins governing protein folding and endoplasmic reticulum stress
Evan A. Elko, Allison M. Manuel, Sheryl L. White, Ester Zito, Albert van der Vliet, Vikas Anathy, Yvonne Janssen‐Heininger
Abstract
modification in the formation of HMW PRDX4 complexes in cells, whereas the association of key regulators of ER homeostasis with HMW oxidized PRDX4 point to a putative role of PRDX4 in regulating ER stress responses.
Topics & Concepts
Endoplasmic reticulumUnfolded protein responseCell biologyFolding (DSP implementation)Protein foldingPeroxiredoxinChemistryBiochemistryBiologyEnzymeEngineeringElectrical engineeringPeroxidaseRedox biology and oxidative stressEndoplasmic Reticulum Stress and DiseaseHeat shock proteins research